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Radiolab ·Sep 18, 2026 ·31 min

The Sweetest Thing

Evaluation and Summary

7.9/10

Radiolab's 'The Sweetest Thing' follows co-host Latif Nasser on a quest sparked by his sons' simple question: what is the sweetest thing in the world? The episode explores multiple candidates for ultimate sweetness, including the West African Katemfe berry, industrial sugar substitutes developed in laboratories, and common pantry ingredients. Rather than settling on a single answer, the episode uses sweetness as a lens to examine deeper questions about taste perception, sensory biology, and human desire. The reporting draws on interviews with leading experts: experimental psychologist Charles Spence at Oxford, sweetness chemist Grant DuBois, Danielle Reed from the Monell Chemical Senses Center, and nutritional scientist Sarah Berry at King's College London. The episode also features food experts Nicola Twilley and Cynthia Graber from Gastropod, as well as celebrity food personalities Claire Saffitz and Sam Seneveratne, who participated in a live version at the Tribeca Festival. Key themes include how our tongues and unexpected body parts determine taste preferences, the chemistry behind artificial sweeteners, and the psychology of desire for increasingly sweet experiences. The episode appears to blend scientific investigation with personal narrative, using Nasser's family moment as an entry point to broader questions about sensory perception and food science. The production is notably polished, with original sonic composition by Jialin Deng and hosted at Columbia University's Mortimer B Zuckerman Mind Brain Behavior Institute. The episode includes citations to published articles on sugar redesign, the history of sweetness, and even sugar in space, suggesting substantive research backing. At 31 minutes, the episode balances accessibility with scientific depth, featuring multiple expert perspectives while remaining grounded in a relatable personal question. The Tribeca Festival connection and involvement of well-known food media figures (Gastropod, Saffitz) suggests high production values and credible sourcing. The episode promises to challenge listeners' assumptions about what sweetness actually is, moving beyond simple taste to explore the neuroscience and chemistry underlying one of humanity's most fundamental sensory experiences.

Verdict: A well-researched, expertly-produced episode that uses a charming personal question to explore genuine science about taste, chemistry, and sensory perception with credible sources and polished execution.

Science rubric

  • Scientific accuracy 4/5 20%

    Multiple credentialed experts (Oxford psychologist, Monell chemist, King's College nutritionist) consulted; citations provided; no obvious red flags in framing, though depth cannot be fully verified from notes alone.

  • Clarity for non-experts 4/5 20%

    Framed around accessible personal question (child's query) with expert voices; Radiolab's trademark style makes science digestible; 31 minutes suggests pacing for general audience.

  • Sense of discovery 4/5 15%

    Explores unexpected angles (body parts beyond tongue, industrial alternatives, pantry ingredients); questions fundamental assumptions about sweetness; fresh framing of familiar topic.

  • Substance 4/5 15%

    Multiple expert interviews, cited research, exploration of chemistry and psychology; personal narrative anchors content; 31 minutes with this guest roster suggests substantive material without excessive padding.

  • Delivers on its title 5/5 15%

    Title directly matches episode premise (quest to find sweetest thing); description promises exploration of what sweetness is and how we perceive it; both delivered according to notes.

  • Value for time 4/5 15%

    31 minutes is tight for multiple expert interviews and narrative arc; Radiolab known for efficient pacing; length appears justified by scope, though some padding likely present.

How we score Science

Worth it if you enjoy Radiolab's signature blend of personal narrative and scientific curiosity, or have genuine interest in food science, sensory perception, and the chemistry of taste.

Based on the episode description. AI-generated; it can be wrong.

Show notes

“What is the sweetest thing in the world?” After co-host Latif Nasser’s sons ask him this deceptively simple question, he goes on a quest to find it. Is it a West African Katemfe berry? Or an industrial sugar substitute cooked up in a lab? Or an ingredient hiding in plain sight in all of our pantries? A simple mystery that will make you question what sweetness even is, how our tongues (and other body parts you wouldn’t expect) determine what we like, and how far you would go to taste something sweeter than anyone has ever experienced. Thank you to Latif’s sons for indulging us, to Nicola Twilley and Cynthia Graber at Gastropod, to Anni Laffitte, Nazli Parvizi at Museum of Food and Drink, to food icons Claire Saffitz and Sam Seneveratne who did a live show version of this episode with us at the Tribeca Festival. And thank you to Davy Gardner and his wonderful team of audio folks at the Tribeca Festival. Thank you to Jialin Deng who composed the song that was our ‘sonic seasoning’. And to Laura Rickman and everyone else at Columbia University’s Mortimer B Zuckerman Mind Brain Behavior Institute for hosting us. And big thanks to experimental psychologist Charles Spence at Oxford, sweetness chemist Grant DuBois, Danielle Reed at Monell Chemical Senses Center, and nutritional scientist Sarah Berry at King’s College London who all talked to us about their research. And Brian Everett of Honest Organic Farms . And a very special thanks to Sean Oomens, inventor of producer Jess Yung’s favorite candy, nerd gummy clusters EPISODE CREDITS: Reported by - Latif Nasser with help from - Jessica Yung, Maria Paz Gutierrez, Jessica Yung, Ekedi Fausther-Keeys, and Natalia Ramirez Produced by - Jessica Yung with help from - Mona Madgavkar, Maria Paz Gutierrez, Gabby Santas, and Maia Appleby Melamed with mixing help from - Jeremy Bloom Fact-checking by - Sophie Samiee and Edited by - Pat Walters EPISODE CITATIONS: Videos: Youtuber Chemiolis tried to make Luguduname himself ( https://zpr.io/MmUbGfwwFrFH ) Articles - Race to Redesign Sugar ( https://zpr.io/VpsMxfPRbxaz ) by Nicola Twilley The Search for Sweet ( https://zpr.io/JmeDkVhrd2dK ) by Burkhard Bilger How My Trip to Quit Sugar Became A Journey Into Hell ( https://zpr.io/ni6xgC38Qmyf ) by Caity Wever How Much of Our Existence Do We Owe to Sugar? ( https://zpr.io/M2py48SxnQAT ) by Jackie Flynn Mogensen Scientists Find Sugar In Space ( https://zpr.io/e94UtUuhPtbT ) by Rebecca Dzombak Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Episode page

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