← StarTalk with Neil deGrasse Tyson
StarTalk with Neil deGrasse Tyson ·Sep 4, 2026 ·1h 14m

This Is Your Brain on Psychedelics

Evaluation and Summary

5.9/10

StarTalk explores psychedelic science with neuroscientist Gül Dölen, examining how psychedelics might reopen critical periods in the brain—windows of heightened neuroplasticity normally associated with childhood development. The episode promises to investigate cutting-edge research on how these substances affect brain function and learning, with a playful angle: what high octopuses reveal about human neurobiology. Neil deGrasse Tyson hosts alongside Chuck Nice and Gary O'Reilly. The framing suggests the conversation will bridge popular science communication with legitimate neuroscience, touching on brain development, neuroplasticity, and the mechanisms by which psychedelics might influence cognition. The show notes emphasize the expert credentials of the guest and the novelty of the research angle, positioning this as accessible science journalism rather than advocacy or medical advice.

Verdict: A well-positioned episode with a credible expert and genuinely novel research angle, but limited source material prevents confident assessment of execution, pacing, and actual scientific depth.

Science rubric

  • Scientific accuracy n/a

    Show notes don't provide enough detail about specific claims made or how they're presented; Dölen's expertise suggests credibility but actual accuracy of statements cannot be assessed from description alone.

  • Clarity for non-experts 3/5 25%

    StarTalk's format with Tyson and comedians (Nice, O'Reilly) suggests accessible framing, but show notes don't confirm whether complex neuroscience is explained clearly or remains jargon-heavy.

  • Sense of discovery 4/5 19%

    The angle of psychedelics reopening critical periods and the octopus example signal genuinely novel research territory; this appears to be cutting-edge neuroscience rather than rehashed material.

  • Substance 3/5 19%

    A 74-minute episode with one expert guest and comedic hosts suggests solid content potential, but show notes don't detail depth, tangents, or filler; structure unclear.

  • Delivers on its title 4/5 19%

    Title promises exploration of how psychedelics affect the brain; description confirms focus on brain plasticity, critical periods, and psychedelic mechanisms—directly on-topic.

  • Value for time 3/5 19%

    74 minutes is moderate length for a deep-dive interview; pacing cannot be assessed from show notes, but the presence of comedic co-hosts suggests conversational flow rather than dense lecture.

How we score Science

Worth it if you're curious about how psychedelics reshape the brain and enjoy Neil deGrasse Tyson's accessible science communication style.

Content flags

  • Ad-heavy Show notes emphasize StarTalk+ ad-free option and SiriusXM subscription pitch; standard for the network but notable relative to content length.

Based on the episode description. AI-generated; it can be wrong.

Show notes

What if you could reopen your childhood brain? Neil deGrasse Tyson, Chuck Nice, and Gary O’Reilly explore the cutting edge of psychedelic science, critical periods, and what a high octopus can teach us about the human mind with neuroscientist and psychedelics expert Gül Dölen. NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: https://startalkmedia.com/show/this-is-your-brain-on-psychedelics/ Thanks to our Patrons Edward Tuten, CJP, David Williamson, Shelsea Evans, Curious1, brittanivstheworld, Mark Huth, Annmarie Pine, Austin Wiggins, John Sprot, T.C. Polk, David Rossi, Murat Tahtali, Levi Jackson, Jeff L Kelly, Average Joe Paracord, gert alex, Ruthanne, joe, Arash Ghorbani, Fretbuzz Lightyear, Cody Asbury, Doyle Vann, APwater, Daniel Baker, K, Adam Boyher, Thom@0, Michael D Saladino, Cyrus Niccore, Lance W Roberts, Merix Style, Serhii Rieznik, slowbrow, Kamil Ignatowski, Dustin DeRollo, Jake Spector, Teemu Rönkkö, Kamron Barker, Chris Michel, Lee Patrick Anderson, Adam Deeb, Joshua10902, Arash Mehrnama, Juliejon Rondeau, Nickolaos Podias, Alex Seymour, Robert Harwood, William Ridout, Enck, Ryan Robertson, Fi Higgins, Roger Wacker, Bryce Weicht, Max, Burgai Atal, Misselvira, Kangee Gold, Bill Beauregard, and Jim Derych for supporting us this week. Subscribe to SiriusXM Podcasts+ to listen to new episodes of StarTalk Radio ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus . Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Episode page

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