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The Autoimmune Wellness Podcast ·Oct 5, 2026 ·52 min

ADHD, Women’s Health, and Autoimmune Disease with Dr. Jolene Brighten (Ep 99)

Evaluation and Summary

7.4/10

Episode 99 of The Autoimmune Wellness Podcast features Dr. Jolene Brighten, a hormone expert and nutrition scientist, discussing the intersection of ADHD, women's health, and autoimmune disease with host Mickey Trescott. The episode addresses a critical gap in women's healthcare: why ADHD often goes undiagnosed in women until later in life and how it presents differently than in men. The conversation explores how estrogen and progesterone fluctuations throughout the menstrual cycle can amplify or mask ADHD symptoms, and how perimenopause may unmask previously compensated ADHD. A significant portion covers hormone replacement therapy (HRT) and its effects on the ADHD brain—an underexplored topic for many women. The episode examines the bidirectional relationship between ADHD, inflammation, and autoimmune disease, suggesting these conditions may share underlying mechanisms. Practical content includes discussion of microbiome support (framed as "microdosing your microbiome"), food sensitivities and their interaction with ADHD symptoms, and concrete strategies for managing overwhelm through nutrition, movement, and lifestyle adjustments. The episode is well-structured with a detailed timeline covering eight distinct segments across 52 minutes, suggesting substantive exploration of each topic rather than surface-level coverage. Dr. Brighten brings relevant credentials as a hormone specialist and bestselling author with a dedicated book on ADHD in women, lending authority to the discussion. The episode appears to deliver directly on its title promise, covering the promised intersection of ADHD, women's health, and autoimmune disease without apparent tangents. The show notes indicate practical takeaways alongside conceptual understanding—listeners learn both "why" (hormonal mechanisms, brain differences) and "how" (strategies for nutrition, movement, overwhelm management). The resource list points to Dr. Brighten's book and website for deeper exploration, suggesting the episode serves as an entry point rather than exhaustive treatment. The pacing across 52 minutes with eight segments suggests reasonable density without obvious padding, though the show notes alone cannot confirm whether discussion includes adequate nuance, research citations, or acknowledgment of knowledge gaps.

Verdict: A well-structured episode with a qualified expert delivering on its title promise, covering an underserved topic (ADHD in women) with both conceptual depth and practical strategies, though show notes alone cannot confirm research rigor or nuance.

Health & Fitness rubric

  • Evidence-based claims 3/5 20%

    Guest is a qualified hormone expert discussing established connections (estrogen/ADHD, perimenopause effects, gut-brain axis) but show notes don't specify research citations or caveats about emerging versus settled science.

  • Expert credentials 4/5 20%

    Dr. Jolene Brighten is a nutrition scientist, hormone specialist, and bestselling author with a dedicated book on ADHD in women, providing strong relevant qualifications.

  • Safe and practical advice 4/5 15%

    Episode emphasizes practical strategies (nutrition, movement, microbiome support, overwhelm reduction) and discusses HRT thoughtfully; no red flags for extreme or risky claims evident in show notes.

  • Substance 4/5 15%

    Eight distinct segments across 52 minutes with specific topics (menstrual cycle effects, perimenopause, HRT, autoimmune links, microbiome, food sensitivities) suggest dense content; show notes indicate both conceptual and practical material

  • Delivers on its title 5/5 15%

    Title promises ADHD, women's health, and autoimmune disease; episode timeline and description cover all three domains and their intersections directly.

  • Value for time 4/5 15%

    52 minutes with eight focused segments and a detailed timeline suggests efficient pacing; no obvious padding evident, though show notes alone cannot confirm absence of tangents.

How we score Health & Fitness

Worth it if you're a woman with undiagnosed or recently diagnosed ADHD, managing autoimmune disease alongside attention challenges, or curious about how hormones shape ADHD presentation across the lifespan.

Based on the episode description. AI-generated; it can be wrong.

Show notes

Episode 99: ADHD, Women’s Health, and Autoimmune Disease with Dr. Jolene Brighten What if the brain fog, overwhelm, forgetfulness, trouble focusing, or emotional intensity you’ve been blaming on hormones or autoimmune disease has another layer to it? In this episode of the Autoimmune Wellness Podcast, Mickey Trescott is joined by hormone expert, nutrition scientist, and bestselling author Dr. Jolene Brighten for a conversation about ADHD through the lens of women’s hormones, brain health, and autoimmune disease. Together, they explore why ADHD can look different in women and why so many women aren’t diagnosed until later in life. They discuss how ADHD symptoms can shift throughout the menstrual cycle and become especially challenging during perimenopause, as well as the complex relationship between hormones, inflammation, the gut, and the brain. Dr. Brighten also shares her perspective on hormone replacement therapy for women with ADHD, practical ways to support the microbiome, and simple strategies for making nutrition, movement, and daily life more ADHD-friendly. In this episode, you'll learn: Why ADHD often looks different in women and can go undiagnosed for decades What’s happening in the ADHD brain beyond problems with attention How estrogen, progesterone, and the menstrual cycle can influence ADHD symptoms Why perimenopause may reveal ADHD that was previously masked or well-compensated What women with ADHD should know about hormone replacement therapy What we know about the relationship between ADHD, inflammation, and autoimmune disease How gut health and food sensitivities may interact with ADHD symptoms Practical strategies for nutrition, movement, and reducing overwhelm with ADHD Resources: Book: ADHD and Women by Dr. Jolene Brighten ADHD and Women resources and bonuses: drbrighten.com/adhdinwomen Podcast: The Dr. Brighten Show Follow Dr. Jolene Brighten: @drjolenebrighten Episode Timeline: 00:00 – ADHD, hormones, and autoimmune disease 01:59 – Introducing Dr. Jolene Brighten 04:10 – How ADHD presents in women 06:48 – What is going on in an ADHD brain? 11:19 – How ADHD symptoms change throughout the menstrual cycle 16:42 – How perimenopause affects ADHD 24:57 – How HRT can affect the ADHD brain 33:44 – The relationship between autoimmune disease and ADHD 37:58 – How to “microdose your microbiome” 43:12 – Food sensitivities and ADHD 45:54 – How to tackle overwhelm with ADHD 49:40 – Wrap-up and closing

Episode page

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